Arginase

Arginase is an enzyme that plays a crucial role in the urea cycle, which is the process of detoxifying ammonia in the body. It is the final enzyme in the cycle, converting L-arginine into L-ornithine and urea.

Function

Arginase catalyzes the fifth and final step in the urea cycle, a series of biochemical reactions in mammals during which the body disposes of harmful ammonia. It converts L-arginine into L-ornithine and urea. The produced urea is then excreted in the urine by the kidneys. The L-ornithine is used in the body to make proline, which is important for cell division, wound healing, and immune function.

Clinical significance

Deficiency in arginase is a rare genetic disorder known as arginase deficiency, which is characterized by a buildup of arginine and ammonia in the blood. Symptoms can include developmental delay, seizures, stiff movement, and spasticity. Treatment typically involves a low-protein diet and medications to help remove ammonia from the body.

See also

• Urea cycle
• Arginase deficiency
• L-arginine
• L-ornithine

References

Arginase Resources
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