Arsenical keratosis
A skin condition caused by chronic arsenic exposure
Arsenical keratosis[edit | edit source]
Arsenical keratosis is a dermatological condition characterized by the development of small, corn-like growths on the skin, primarily on the palms and soles. These lesions are a result of chronic exposure to arsenic, a toxic metalloid that can be found in contaminated water, certain pesticides, and industrial processes.
Pathophysiology[edit | edit source]
Arsenical keratosis occurs due to the accumulation of arsenic in the skin over time. Arsenic interferes with cellular processes, leading to hyperkeratosis, which is the thickening of the outer layer of the skin. This condition is often associated with long-term exposure to arsenic, which can occur through ingestion, inhalation, or dermal contact.
Clinical presentation[edit | edit source]
Patients with arsenical keratosis typically present with multiple, small, hard, and scaly lesions on the palms and soles. These lesions may be skin-colored or slightly pigmented. Over time, they can become more pronounced and may coalesce into larger plaques. In some cases, arsenical keratosis can progress to squamous cell carcinoma, a type of skin cancer.
Diagnosis[edit | edit source]
The diagnosis of arsenical keratosis is primarily clinical, based on the characteristic appearance of the lesions and a history of arsenic exposure. A skin biopsy may be performed to confirm the diagnosis and rule out malignancy. Laboratory tests can also be conducted to measure arsenic levels in the body.
Treatment[edit | edit source]
The primary treatment for arsenical keratosis involves the removal of the source of arsenic exposure. Topical treatments, such as keratolytic agents, can be used to reduce the thickness of the lesions. In some cases, surgical removal or laser therapy may be necessary. Regular monitoring is important to detect any malignant transformation early.
Prevention[edit | edit source]
Preventing arsenical keratosis involves reducing exposure to arsenic. This can be achieved by ensuring access to clean drinking water, using protective equipment in industrial settings, and avoiding the use of arsenic-containing pesticides.
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