Atrophic gastritis

Atrophic Gastritis

Endoscopic view of atrophic gastritis.

Atrophic Gastritis

Atrophic gastritis is a chronic condition characterized by inflammation and progressive wasting away of the stomach lining, leading to the loss of glands that produce stomach acid.

Overview

Atrophic gastritis involves gradual damage and thinning of the gastric mucosa, which is responsible for the production of stomach acid and digestive enzymes. This condition can lead to various digestive problems and nutritional deficiencies.

Pathophysiology

The process of atrophy in the stomach lining involves:

• Inflammation of the gastric mucosa
• Thinning and loss of the protective layer of the stomach
• Reduction or absence of acid-producing gastric glands

Causes

Atrophic gastritis can be caused by several factors, including:

• Helicobacter pylori infection, a common cause of chronic gastritis
• Autoimmune reactions, where the body's immune system mistakenly attacks stomach cells
• Long-term use of certain medications, such as proton pump inhibitors

Symptoms

Symptoms of atrophic gastritis can include:

• Abdominal discomfort or pain
• Nausea and vomiting
• Bloating and indigestion
• Loss of appetite
• Weight loss

Diagnosis

Diagnosis of atrophic gastritis typically involves:

• Endoscopic examination of the stomach
• Biopsy of stomach tissue
• Blood tests to detect Helicobacter pylori infection or autoimmune markers

Treatment

Treatment options depend on the underlying cause but may include:

• Antibiotics to treat Helicobacter pylori infection
• Medications to reduce stomach acid
• Dietary changes and supplements to address nutritional deficiencies

Complications

If left untreated, atrophic gastritis can lead to complications like:

• Pernicious anemia due to vitamin B12 deficiency
• Increased risk of gastric cancer

Atrophic gastritis Resources
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