BC200 lncRNA

BC200 lncRNA is a long non-coding RNA (lncRNA) that is approximately 200 nucleotides in length. It was first discovered in the brain of humans and other primates, hence the name "Brain Cytoplasmic 200" or BC200. BC200 lncRNA plays a significant role in neuronal protein synthesis and dendritic transport, and its dysregulation has been implicated in various neurodegenerative diseases and cancers.

Structure

BC200 lncRNA is composed of three distinct regions: a unique 5' domain, a central adenine-rich region, and a 3' domain that is similar to the Alu element. The 5' domain is involved in the interaction with synaptic proteins, while the 3' Alu-like domain is responsible for the RNA's stability and localization.

Function

BC200 lncRNA is primarily expressed in the neurons of the primate brain, particularly in the dendrites, where it regulates local protein synthesis. It interacts with several proteins involved in translation, including eukaryotic initiation factor 4A (eIF4A) and poly(A)-binding protein (PABP).

In addition to its role in the brain, BC200 lncRNA is also aberrantly expressed in several types of cancer, including breast cancer, lung cancer, and colorectal cancer. It is believed to promote cancer progression by regulating cell proliferation, migration, and invasion.

Clinical Significance

Due to its involvement in various diseases, BC200 lncRNA is being studied as a potential biomarker for disease diagnosis and prognosis. For instance, high levels of BC200 lncRNA in tumor tissues have been associated with poor prognosis in cancer patients. Moreover, BC200 lncRNA has been implicated in neurodegenerative diseases such as Alzheimer's disease, where it is found to be upregulated in the affected brain regions.

See Also

• Long non-coding RNA
• Neurodegenerative diseases
• Cancer

References

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