BRAP (gene)
BRAP (BRCA1 Associated Protein) is a protein that in humans is encoded by the BRAP gene. This protein is known to interact with the product of the BRCA1 gene, which is a significant factor in the development of hereditary breast and ovarian cancer.
Function[edit | edit source]
The BRAP gene encodes a protein that functions as an inhibitor of the RAS proto-oncogene, which plays a crucial role in cell cycle progression, apoptosis, and cellular transformation. The encoded protein also interacts with the E2F1 transcription factor and confers a strong suppressive effect on E2F-dependent transcriptional activity.
Clinical Significance[edit | edit source]
Mutations in the BRAP gene have been associated with an increased risk of myocardial infarction and coronary artery disease. Studies have shown that the BRAP gene may play a role in the pathogenesis of these diseases by modulating the inflammatory response and other processes.
Interactions[edit | edit source]
BRAP has been shown to interact with:
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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