BRAP (gene)

BRAP (BRCA1 Associated Protein) is a protein that in humans is encoded by the BRAP gene. This protein is known to interact with the product of the BRCA1 gene, which is a significant factor in the development of hereditary breast and ovarian cancer.

Function

The BRAP gene encodes a protein that functions as an inhibitor of the RAS proto-oncogene, which plays a crucial role in cell cycle progression, apoptosis, and cellular transformation. The encoded protein also interacts with the E2F1 transcription factor and confers a strong suppressive effect on E2F-dependent transcriptional activity.

Clinical Significance

Mutations in the BRAP gene have been associated with an increased risk of myocardial infarction and coronary artery disease. Studies have shown that the BRAP gene may play a role in the pathogenesis of these diseases by modulating the inflammatory response and other processes.

Interactions

BRAP has been shown to interact with:

• BRCA1
• RAS
• E2F1

See Also

• BRCA1
• RAS
• E2F1
• Myocardial infarction
• Coronary artery disease

External Links

• BRAP gene on NCBI