BZP

Benzylpiperazine (BZP) is a recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. Adverse effects have been reported following its use including acute psychosis, renal toxicity and seizures. No deaths have been reported following a sole ingestion of BZP, although there have been at least two deaths from the combination of BZP and MDMA. Its sale is banned in several countries, including Australia, Canada, New Zealand, the United States, the Republic of Ireland, the United Kingdom, Bulgaria, Romania and other parts of Europe.

History

It is often claimed that BZP was originally synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals. However, there are some references to BZP in medical literature that predate interest in piperazines as antihelminthics. It was discovered that BZP had side effects and was abandoned as a worm treatment.

Pharmacodynamics

BZP is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), and also a serotonin receptor agonist. The stimulant effects of BZP are mediated by its enhancement of dopaminergic neurotransmission.

Legal status

BZP is classified as a Schedule I controlled substance in the United States, and is similarly controlled in other parts of the world. Its sale is banned in several countries, including Australia, Canada, New Zealand, the United States, the Republic of Ireland, the United Kingdom, Bulgaria, Romania and other parts of Europe.

See also

• Piperazine
• Party pills
• MDMA
• Amphetamine

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