Basophil cell

Basophil cell is a type of white blood cell that plays a crucial role in the immune system. Basophils are the least common of the granulocytes, constituting about 0.01% to 0.3% of circulating white blood cells. Despite their rarity, they are important players in immune response, particularly in response to parasitic infections and in allergic reactions.

Function[edit | edit source]

Basophils contain large cytoplasmic granules which store and release histamine and heparin. Histamine is a chemical that contributes to inflammatory response, while heparin is an anticoagulant. When an allergen enters the body, it triggers the basophils to release these chemicals, leading to inflammation and other symptoms of an allergic reaction.

Development[edit | edit source]

Basophils are produced in the bone marrow from stem cells. They mature in the bone marrow before being released into the bloodstream. The lifespan of a basophil in the circulation is typically 1-2 days.

Role in Disease[edit | edit source]

Basophils play a role in several diseases. In allergic reactions, they are responsible for the release of histamine and other chemicals that cause symptoms. They are also involved in autoimmune diseases, where they can contribute to inflammation and tissue damage. In addition, elevated basophil counts can be a sign of certain types of leukemia or other blood disorders.