Benzonitrile

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Benzonitrile is an organic compound with the chemical formula C7H5N. It is the simplest aromatic nitrile, consisting of a benzene ring attached to a nitrile group. Benzonitrile is a colorless liquid that has a distinct almond-like odor, making it identifiable in various chemical settings. It is used as a solvent and as an intermediate in the synthesis of other compounds, including pharmaceuticals, agrochemicals, and dyes.

Properties[edit | edit source]

Benzonitrile is a polar molecule due to the presence of the nitrile group. It has a boiling point of 191°C and a melting point of -13°C. Being an aromatic compound, benzonitrile exhibits typical aromatic stability and undergoes reactions characteristic of both benzene and nitriles. It is slightly soluble in water but highly soluble in organic solvents such as ethanol, diethyl ether, and acetone.

Synthesis[edit | edit source]

Benzonitrile can be synthesized through several methods. One common method is the dehydration of benzamide using phosphorus pentoxide (P2O5) as a dehydrating agent. Another method involves the ammoxidation of toluene, where toluene is reacted with ammonia and oxygen in the presence of a catalyst to form benzonitrile and water.

Applications[edit | edit source]

Benzonitrile is primarily used as a solvent in the extraction of various chemicals and as an intermediate in the synthesis of pharmaceuticals, pesticides, herbicides, dyes, and aromatics. Its ability to dissolve a wide range of compounds makes it valuable in the chemical industry. Additionally, benzonitrile derivatives are explored for their potential in organic electronics and as ligands in transition metal catalysis.

Safety and Environmental Impact[edit | edit source]

Benzonitrile is toxic if ingested, inhaled, or absorbed through the skin. It can cause respiratory and skin irritation. Proper handling and safety equipment are essential when working with this chemical. In the environment, benzonitrile can degrade through photolytic and microbial processes, though its persistence and impact vary depending on specific conditions.

See Also[edit | edit source]

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Contributors: Prab R. Tumpati, MD