Benzonitrile

From WikiMD's Wellness Encyclopedia

Rosenmund-von Braun synthesis.svg

Benzonitrile is an organic compound with the chemical formula C7H5N. It is the simplest aromatic nitrile, consisting of a benzene ring attached to a nitrile group. Benzonitrile is a colorless liquid that has a distinct almond-like odor, making it identifiable in various chemical settings. It is used as a solvent and as an intermediate in the synthesis of other compounds, including pharmaceuticals, agrochemicals, and dyes.

Properties[edit | edit source]

Benzonitrile is a polar molecule due to the presence of the nitrile group. It has a boiling point of 191°C and a melting point of -13°C. Being an aromatic compound, benzonitrile exhibits typical aromatic stability and undergoes reactions characteristic of both benzene and nitriles. It is slightly soluble in water but highly soluble in organic solvents such as ethanol, diethyl ether, and acetone.

Synthesis[edit | edit source]

Benzonitrile can be synthesized through several methods. One common method is the dehydration of benzamide using phosphorus pentoxide (P2O5) as a dehydrating agent. Another method involves the ammoxidation of toluene, where toluene is reacted with ammonia and oxygen in the presence of a catalyst to form benzonitrile and water.

Applications[edit | edit source]

Benzonitrile is primarily used as a solvent in the extraction of various chemicals and as an intermediate in the synthesis of pharmaceuticals, pesticides, herbicides, dyes, and aromatics. Its ability to dissolve a wide range of compounds makes it valuable in the chemical industry. Additionally, benzonitrile derivatives are explored for their potential in organic electronics and as ligands in transition metal catalysis.

Safety and Environmental Impact[edit | edit source]

Benzonitrile is toxic if ingested, inhaled, or absorbed through the skin. It can cause respiratory and skin irritation. Proper handling and safety equipment are essential when working with this chemical. In the environment, benzonitrile can degrade through photolytic and microbial processes, though its persistence and impact vary depending on specific conditions.

See Also[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD