Beta-3 adrenergic receptor
Beta-3 adrenergic receptor (ADRB3) is a protein that in humans is encoded by the ADRB3 gene. It is a member of the adrenergic receptor group of G protein-coupled receptors.
Function[edit | edit source]
The Beta-3 adrenergic receptor is located mainly in adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Some researchers believe that in humans, this receptor could be used to treat obesity and diabetes.
Clinical significance[edit | edit source]
The Beta-3 adrenergic receptor has been the subject of research in the treatment of obesity and diabetes. Some beta-3 agonists have been developed for the treatment of these conditions, but their clinical use is still under investigation.
Pharmacology[edit | edit source]
Beta-3 adrenergic receptors are stimulated by norepinephrine and epinephrine. When activated, they trigger a cascade of intracellular events that result in the breakdown of fat. Beta-3 adrenergic receptors are also found in the gallbladder, urinary bladder, and in brown adipose tissue, where their activation can increase lipolysis and thermogenesis.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Human ADRB3 database page in IUPHAR
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Contributors: Prab R. Tumpati, MD
