Beta-Fuoxymorphamine

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Beta-Fuoxymorphamine.svg

Beta-Fuoxymorphamine is a potent opioid receptor agonist that is structurally related to oxymorphone. It is primarily used in scientific research to study the opioid receptor system.

Chemical Structure and Properties

Beta-Fuoxymorphamine is a derivative of morphine, with modifications that enhance its affinity and selectivity for the mu-opioid receptor. The chemical structure of Beta-Fuoxymorphamine includes a furan ring, which distinguishes it from other morphine derivatives.

Pharmacology

Beta-Fuoxymorphamine exhibits high affinity for the mu-opioid receptor, which is responsible for its potent analgesic effects. It also interacts with the delta-opioid receptor and kappa-opioid receptor, although with lower affinity. The activation of these receptors leads to the inhibition of adenylate cyclase activity, reduction in cAMP levels, and subsequent modulation of neurotransmitter release.

Research Applications

Due to its high potency and selectivity, Beta-Fuoxymorphamine is used in neuroscience research to investigate the mechanisms of opioid receptor activation and signal transduction. It is also employed in studies exploring the development of tolerance and dependence associated with opioid use.

Safety and Handling

As with other potent opioids, Beta-Fuoxymorphamine must be handled with care in a controlled laboratory environment. Proper safety protocols, including the use of personal protective equipment (PPE) and adherence to biosafety guidelines, are essential to prevent accidental exposure.

See Also

• Opioid
• Mu-opioid receptor
• Oxymorphone
• Morphine
• Analgesic

External Links

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