Big dynorphin

Big dynorphin is a neuropeptide that is found in the nervous system. It is a large peptide that is derived from the prohormone, prodynorphin. Big dynorphin is known for its role in modulating responses to pain, stress, and addiction.

Structure

Big dynorphin is a 32-amino acid peptide. It is composed of the dynorphin A and dynorphin B sequences, which are connected by a lysine residue. The structure of big dynorphin allows it to interact with kappa opioid receptors in the nervous system.

Function

Big dynorphin functions as a neurotransmitter and neuromodulator in the nervous system. It binds to and activates kappa opioid receptors, which are involved in pain perception, stress response, and the development of addiction. Activation of these receptors by big dynorphin can lead to analgesia, or pain relief. However, it can also produce dysphoria, or a state of unease or dissatisfaction.

Role in Disease

Research has suggested that big dynorphin may play a role in several neurological disorders, including chronic pain, depression, and drug addiction. Elevated levels of big dynorphin have been found in individuals with these conditions, suggesting that it may contribute to their development or progression.

See Also

• Dynorphin
• Kappa opioid receptor
• Neuropeptide
• Neurotransmitter