Brunner syndrome

Brunner syndrome is a rare genetic disorder associated with abnormal production of the enzyme monoamine oxidase A (MAOA). It is characterized by lower than normal intelligence, behavioral problems, and a tendency towards violence. The syndrome is named after Hans Brunner, the Dutch human geneticist who first described it.

Symptoms[edit | edit source]

The symptoms of Brunner syndrome can vary greatly from person to person. However, common symptoms include:

Lower than normal intelligence
Behavioral problems
Tendency towards violence
Impulsivity
Mood swings
Sleep disturbances

Causes[edit | edit source]

Brunner syndrome is caused by mutations in the MAOA gene. This gene provides instructions for making an enzyme called monoamine oxidase A, which is involved in the breakdown of certain chemicals in the brain. Mutations in the MAOA gene lead to reduced activity of this enzyme, which can result in an imbalance of chemicals in the brain and the symptoms of Brunner syndrome.

Diagnosis[edit | edit source]

Diagnosis of Brunner syndrome is based on the presence of characteristic symptoms, a detailed patient history, a thorough clinical evaluation, and a variety of specialized tests. Genetic testing can confirm a diagnosis.

Treatment[edit | edit source]

There is currently no cure for Brunner syndrome. Treatment is symptomatic and supportive, and may include medications to manage symptoms, behavioral therapy, and educational support.

References[edit | edit source]

External links[edit | edit source]

WikiMD: Brunner syndrome

Brunner syndrome Resources
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