Bruns nystagmus

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Bruns Nystagmus

Bruns nystagmus is a type of nystagmus, which is an involuntary, rhythmic oscillation of the eyes. It is named after the German neurologist Ludwig Bruns, who first described this condition. Bruns nystagmus is characterized by a combination of two different types of nystagmus: a slow, large-amplitude nystagmus when looking towards the side of the lesion, and a fast, small-amplitude nystagmus when looking away from the lesion.

Pathophysiology

Bruns nystagmus is typically associated with lesions in the cerebellopontine angle, such as a vestibular schwannoma (also known as an acoustic neuroma). The cerebellopontine angle is a region in the brain where the cerebellum and pons are located, and it is a common site for tumors that can affect the cranial nerves and brainstem.

The nystagmus occurs due to the differential impact of the lesion on the vestibular and ocular motor pathways. When the patient looks towards the side of the lesion, the slow-phase nystagmus is due to the imbalance in vestibular input caused by the lesion. When looking away from the lesion, the fast-phase nystagmus is due to the compensatory mechanisms of the brain trying to stabilize gaze.

Clinical Presentation

Patients with Bruns nystagmus may present with symptoms such as:

The presence of Bruns nystagmus can be a clinical indicator of a mass lesion in the cerebellopontine angle, prompting further investigation with imaging studies such as MRI or CT scan.

Diagnosis

The diagnosis of Bruns nystagmus is primarily clinical, based on the characteristic eye movements observed during an eye examination. The clinician may perform tests such as the head impulse test or electronystagmography to assess the vestibular function and eye movements.

Treatment

Treatment of Bruns nystagmus involves addressing the underlying cause, which is often a tumor in the cerebellopontine angle. Surgical removal of the tumor, such as a vestibular schwannoma, can alleviate the symptoms. In some cases, radiotherapy or stereotactic radiosurgery may be considered.

Prognosis

The prognosis for patients with Bruns nystagmus depends on the underlying cause and the success of treatment. Early detection and management of the causative lesion can lead to a good outcome, with resolution of the nystagmus and associated symptoms.

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Contributors: Prab R. Tumpati, MD