Budipine
Budipine is a medication used in the treatment of Parkinson's disease. It is an antiparkinson agent that functions as an NMDA antagonist, and it also has anticholinergic properties. Budipine was first synthesized in the 1970s and has been used in Germany since 1990 for the treatment of Parkinson's disease.
Mechanism of action[edit | edit source]
Budipine's mechanism of action is not fully understood. It is known to be an NMDA receptor antagonist, which means it inhibits the action of the NMDA receptor, a type of glutamate receptor. Glutamate is a neurotransmitter that plays a role in neural activation. Budipine also has anticholinergic properties, meaning it blocks the action of the neurotransmitter acetylcholine.
Uses[edit | edit source]
Budipine is used in the treatment of Parkinson's disease. It is typically used in combination with other drugs, such as levodopa, to manage the symptoms of the disease. It has been shown to be effective in reducing motor fluctuations and dyskinesias in patients with Parkinson's disease.
Side effects[edit | edit source]
The most common side effects of budipine are dry mouth, constipation, and urinary retention. These are typical side effects of anticholinergic drugs. Other side effects can include blurred vision, dizziness, and confusion.
History[edit | edit source]
Budipine was first synthesized in the 1970s and has been used in Germany since 1990 for the treatment of Parkinson's disease. It is not currently approved for use in the United States.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
