Bufenadrine
An antihistamine drug
Bufenadrine is a chemical compound that functions as an antihistamine. It is primarily used for its ability to alleviate symptoms associated with allergic reactions, such as rhinitis, urticaria, and other allergic conditions.
Chemical Structure and Properties[edit | edit source]
Bufenadrine is classified as an ethanolamine derivative, a group known for their antihistamine properties. The chemical structure of Bufenadrine includes a diphenylmethane moiety, which is common among first-generation antihistamines. This structure contributes to its ability to cross the blood-brain barrier, leading to its sedative effects.
Pharmacology[edit | edit source]
Bufenadrine acts as an H1 receptor antagonist, blocking the action of histamine at the H1 receptor sites. This action prevents the typical symptoms of an allergic reaction, such as itching, swelling, and vasodilation. As a first-generation antihistamine, Bufenadrine can cause sedation and drowsiness, which are common side effects due to its ability to penetrate the central nervous system.
Uses[edit | edit source]
Bufenadrine is used in the treatment of various allergic conditions. It is effective in managing symptoms of:
Side Effects[edit | edit source]
Common side effects of Bufenadrine include:
These side effects are typical of first-generation antihistamines and are primarily due to their non-selective action on the central nervous system.
Mechanism of Action[edit | edit source]
Bufenadrine works by competitively inhibiting the binding of histamine to the H1 receptors. This inhibition prevents the cascade of events that lead to the symptoms of an allergic reaction. By blocking these receptors, Bufenadrine reduces the effects of histamine, such as bronchoconstriction, vasodilation, and increased capillary permeability.
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