Bufotenidine

Bufotenidine is a tryptamine derivative and a minor alkaloid found in the skin of some species of toads, particularly those belonging to the Bufonidae family. It is structurally related to the more well-known compounds bufotenin and 5-MeO-DMT, which are also found in toad venom.

Chemistry

Bufotenidine is a member of the tryptamine class of compounds, which are characterized by a indole ring structure. It is structurally similar to bufotenin, differing only in the position of a hydroxyl group on the indole ring. Bufotenidine is also structurally similar to the potent psychedelic compound 5-MeO-DMT, differing only in the absence of a methoxy group.

Biosynthesis

The biosynthesis of bufotenidine in toad skin is not fully understood. It is believed to involve the decarboxylation of tryptophan to form tryptamine, which is then modified by the addition of a hydroxyl group to form bufotenidine.

Pharmacology

The pharmacological effects of bufotenidine are not well-studied. It is known to be less potent than bufotenin and 5-MeO-DMT, but its specific effects on the human brain are not well understood. It is believed to act as a serotonin receptor agonist, similar to other tryptamines.

Toxicity

The toxicity of bufotenidine is not well-studied. However, it is known that other tryptamines found in toad venom, such as bufotenin and 5-MeO-DMT, can be toxic in high doses. Therefore, it is possible that bufotenidine could also be toxic in high doses.

Legal status

The legal status of bufotenidine varies by country. In some countries, it is classified as a controlled substance due to its structural similarity to other controlled tryptamines.

See also

• Bufotenin
• 5-MeO-DMT
• Tryptamine