C-C chemokine receptor type 6

C-C chemokine receptor type 6 (also known as CCR6) is a protein that in humans is encoded by the CCR6 gene. CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This receptor specifically binds to its ligand CCL20 and is highly expressed in T cells and B cells, and is known to be important in B cell migration into Peyer's patches.

Function

CCR6 is a G protein-coupled receptor that binds the chemokine CCL20. This receptor-ligand interaction leads to the migration of T cells and B cells. The receptor is also expressed on immature dendritic cells, where it is involved in their migration to the epithelium of the gut and skin.

Clinical significance

CCR6 has been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and psoriasis. In addition, it has been suggested that CCR6 plays a role in the progression of certain types of cancer, such as colorectal cancer and breast cancer.

See also

• Chemokine receptor
• CCL20
• G protein-coupled receptor

References

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