C-C chemokine receptor type 6
C-C chemokine receptor type 6 (also known as CCR6) is a protein that in humans is encoded by the CCR6 gene. CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This receptor specifically binds to its ligand CCL20 and is highly expressed in T cells and B cells, and is known to be important in B cell migration into Peyer's patches.
Function[edit | edit source]
CCR6 is a G protein-coupled receptor that binds the chemokine CCL20. This receptor-ligand interaction leads to the migration of T cells and B cells. The receptor is also expressed on immature dendritic cells, where it is involved in their migration to the epithelium of the gut and skin.
Clinical significance[edit | edit source]
CCR6 has been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and psoriasis. In addition, it has been suggested that CCR6 plays a role in the progression of certain types of cancer, such as colorectal cancer and breast cancer.
See also[edit | edit source]
References[edit | edit source]
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