C-jun

C-jun is a protein that in humans is encoded by the JUN gene. C-jun is a component of the transcription factor AP-1 (Activator Protein-1) and belongs to the Jun family of transcription factors, which also includes JunB and JunD.

Structure of the c-jun protein.

Function

C-jun, in combination with c-Fos, forms the AP-1 early response transcription factor. It is activated through double phosphorylation by the JNK pathway but can also be phosphorylated by the ERK pathway. This protein has been implicated in a variety of biological processes, including cell proliferation, apoptosis, and cell differentiation.

Clinical significance

Alterations in the function of c-jun have been associated with several cancer types, including lung cancer, breast cancer, and prostate cancer. Overexpression of c-jun can result in increased cell proliferation and reduced apoptosis, contributing to tumor growth and progression.

Research

Research into the function and regulation of c-jun has potential implications for the development of new cancer therapies. Inhibitors of c-jun are being investigated for their potential to reduce tumor growth and enhance the effectiveness of existing cancer treatments.

See also

• AP-1 (transcription factor)
• Jun family
• Transcription factor
• Cancer