CBLL1

CBLL1 (also known as Casitas B-lineage lymphoma-transforming sequence-like protein 1) is a protein that in humans is encoded by the CBLL1 gene. This protein is a ubiquitin-protein ligase involved in the regulation of signal transduction, transcription, and membrane trafficking.

Function

The CBLL1 protein is a member of the Hakai family of E3 ubiquitin ligases. It functions by adding ubiquitin molecules to specific target proteins, marking them for degradation by the proteasome. This process is known as ubiquitination.

CBLL1 has been shown to ubiquitinate the epidermal growth factor receptor (EGFR), a key player in cell growth and proliferation. By doing so, CBLL1 regulates the amount of EGFR on the cell surface, thereby controlling the strength of the signal that the cell receives.

Clinical significance

Alterations in the CBLL1 gene have been associated with various types of cancer, including breast cancer and lung cancer. In these cases, the CBLL1 protein may be overexpressed, leading to increased degradation of EGFR and a consequent decrease in cell growth signals. This can contribute to the uncontrolled cell growth that characterizes cancer.

Research

Research into the role of CBLL1 in cancer is ongoing. Understanding how this protein functions and how it is regulated could lead to new strategies for cancer treatment.

See also

• Ubiquitin-protein ligase
• Epidermal growth factor receptor
• Proteasome
• Ubiquitination

References

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