CD151

CD151‏‎ (also known as Cluster of Differentiation 151) is a protein that in humans is encoded by the CD151‏‎ gene. It is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Function[edit | edit source]

CD151‏‎ forms complexes with other tetraspanin proteins, integrins, and other proteins and acts as a molecular organizer of a variety of membrane proteins. It is involved in the regulation of cell adhesion and motility. This protein is also involved in the growth of certain types of tumors.

Clinical significance[edit | edit source]

Mutations in the CD151‏‎ gene are associated with the rare genetic condition Epidermolysis bullosa, which causes the skin to become very fragile and to blister easily. In addition, CD151‏‎ has been implicated in the progression of certain types of cancer, including breast cancer and prostate cancer.

Research[edit | edit source]

Research into the function and potential therapeutic uses of CD151‏‎ is ongoing. It is thought that understanding more about this protein could lead to new treatments for a variety of conditions, including skin disorders and cancer.