CD151

CD151‏‎ (also known as Cluster of Differentiation 151) is a protein that in humans is encoded by the CD151‏‎ gene. It is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Function

CD151‏‎ forms complexes with other tetraspanin proteins, integrins, and other proteins and acts as a molecular organizer of a variety of membrane proteins. It is involved in the regulation of cell adhesion and motility. This protein is also involved in the growth of certain types of tumors.

Clinical significance

Mutations in the CD151‏‎ gene are associated with the rare genetic condition Epidermolysis bullosa, which causes the skin to become very fragile and to blister easily. In addition, CD151‏‎ has been implicated in the progression of certain types of cancer, including breast cancer and prostate cancer.

Research

Research into the function and potential therapeutic uses of CD151‏‎ is ongoing. It is thought that understanding more about this protein could lead to new treatments for a variety of conditions, including skin disorders and cancer.

See also

• Cluster of differentiation
• Tetraspanin
• Epidermolysis bullosa
• Breast cancer
• Prostate cancer