CD22

CD22 is a protein that in humans is encoded by the CD22 gene. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion molecule. It is involved in modulating B cell activation and function.

Function

CD22 is a surface molecule found on all mature B cells that functions as an inhibitory receptor during B cell activation. It is a member of the immunoglobulin superfamily and is also known as SIGLEC-2 (Sialic acid-binding Ig-like lectin 2). CD22 plays a role in the interaction between the B cell and its environment, and is involved in the regulation of intracellular calcium ion levels.

Clinical significance

CD22 has been identified as a target for cancer therapy, particularly in the treatment of non-Hodgkin's lymphoma and acute lymphoblastic leukemia. CD22-targeted therapies include monoclonal antibodies and immunotoxins, which deliver cytotoxic agents directly to CD22-expressing cells.

See also

• Cluster of differentiation
• Immunoglobulin superfamily
• B cell
• Non-Hodgkin's lymphoma
• Acute lymphoblastic leukemia

External links

• CD22 at UniProt
• CD22 at NCBI

CD22 Resources
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