CD44
CD44 is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). CD44 is expressed in a large number of mammalian cell types.
Function[edit | edit source]
CD44 participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44 is also involved in inflammation and immune response.
Clinical significance[edit | edit source]
CD44 has been identified as a gene associated with cancer progression and metastatic disease. Aberrant expression of the CD44 gene is linked to a variety of diseases, including breast cancer, colorectal cancer, and gastric cancer.
See also[edit | edit source]
- Cell adhesion
- Glycoprotein
- Hyaluronic acid
- Osteopontin
- Collagens
- Matrix metalloproteinases
- Lymphocyte
- Hematopoiesis
- Tumor metastasis
- Inflammation
- Immune response
- Breast cancer
- Colorectal cancer
- Gastric cancer
References[edit | edit source]
External links[edit | edit source]
- CD44 at WikiMD
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Contributors: Prab R. Tumpati, MD
