CD64

CD64 is a type of protein that in humans is encoded by the FCGR1A gene. It is also known as Fc-gamma RI, and is a member of the immunoglobulin superfamily. CD64 plays a crucial role in the immune system, as it is involved in the process of phagocytosis and cytokine release.

Structure[edit | edit source]

CD64 is a high-affinity Fc receptor, and is composed of a transmembrane domain, a cytoplasmic domain, and three extracellular immunoglobulin domains. The cytoplasmic domain contains an immunoreceptor tyrosine-based activation motif (ITAM), which is essential for triggering immune responses.

Function[edit | edit source]

CD64 is primarily found on the surface of monocytes and macrophages, and is upregulated during inflammation. It binds to the Fc portion of IgG antibodies, and triggers a series of cellular responses including phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and release of cytokines and chemokines.

Clinical significance[edit | edit source]

CD64 is used as a biomarker for distinguishing between bacterial and viral infections. High levels of CD64 are associated with bacterial infections, while low levels are associated with viral infections. It is also used as a marker for systemic lupus erythematosus (SLE), as patients with SLE have been found to have elevated levels of CD64.

See also[edit | edit source]

CD64 Resources
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