CD96

CD96

CD96 is a protein that in humans is encoded by the CD96 gene. It is a member of the immunoglobulin superfamily, and is involved in the regulation of T-cell activation and growth. CD96 is expressed on the surface of natural killer cells and T-cells, and plays a crucial role in the immune response.

Structure

The CD96 protein is a type I transmembrane protein, which means it has a single transmembrane domain that anchors it to the cell membrane. The extracellular portion of the protein contains three immunoglobulin-like domains, which are involved in binding to other proteins.

Function

CD96 plays a key role in the immune response by regulating the activation and growth of T-cells. It does this by binding to its ligand, CD155, which is expressed on the surface of antigen-presenting cells. This interaction triggers a series of intracellular signals that lead to T-cell activation and proliferation.

In addition to its role in T-cell activation, CD96 also plays a role in the function of natural killer cells. It has been shown to inhibit the killing activity of these cells, suggesting that it may play a role in regulating the immune response to prevent excessive tissue damage.

Clinical significance

Alterations in the expression or function of CD96 have been implicated in a number of diseases, including cancer and autoimmune diseases. In particular, high levels of CD96 expression have been associated with poor prognosis in several types of cancer, including leukemia and lung cancer. This has led to interest in targeting CD96 for cancer therapy.

See also

• CD155
• T-cell
• Natural killer cell
• Immunoglobulin superfamily
• Transmembrane protein