CHOP (chemotherapy)
CHOP is a chemotherapy regimen for non-Hodgkin lymphoma (NHL) consisting of four drugs: Cyclophosphamide, Hydroxydaunorubicin, Oncovin, and Prednisone. The regimen has been in use since the 1970s.
Overview[edit | edit source]
CHOP is used to treat non-Hodgkin lymphoma, including diffuse large B-cell lymphoma (DLBCL). The regimen is given in cycles, with each cycle typically lasting three weeks. Patients usually receive six to eight cycles.
Components[edit | edit source]
The CHOP chemotherapy regimen consists of the following drugs:
- Cyclophosphamide: An alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis.
- Hydroxydaunorubicin (also known as Doxorubicin): An anthracycline that intercalates DNA, inhibits topoisomerase II, and creates free radicals.
- Oncovin (also known as Vincristine): A vinca alkaloid that inhibits mitosis by binding to tubulin.
- Prednisone: A corticosteroid that induces apoptosis in lymphocytes.
Side Effects[edit | edit source]
Like all chemotherapy regimens, CHOP has potential side effects, including nausea, vomiting, hair loss, and fatigue. More serious side effects can include cardiotoxicity and neutropenia.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
