CHRNA2

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CHRNA2 is a gene that encodes the alpha-2 subunit of the nicotinic acetylcholine receptor (nAChR). The nAChR is a type of ionotropic receptor that is activated by the neurotransmitter acetylcholine. The CHRNA2 gene is located on the long arm of chromosome 8 (8q21.3).

Function[edit | edit source]

The CHRNA2 gene is part of a family of genes that encode the subunits of the nicotinic acetylcholine receptors. These receptors are found in the central nervous system and play a crucial role in neurotransmission. The alpha-2 subunit encoded by the CHRNA2 gene is one of several different subunits that can combine to form a functional nAChR. The specific combination of subunits determines the receptor's functional properties, such as its sensitivity to different neurotransmitters and drugs.

Clinical significance[edit | edit source]

Mutations in the CHRNA2 gene have been associated with a variety of neurological disorders. For example, a rare mutation in this gene has been linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), a form of epilepsy characterized by nocturnal seizures that originate in the frontal lobe of the brain. Other studies have suggested a possible association between variations in the CHRNA2 gene and susceptibility to nicotine addiction and schizophrenia, although more research is needed to confirm these findings.

See also[edit | edit source]

References[edit | edit source]


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