CHRNA3

CHRNA3 or Cholinergic Receptor Nicotinic Alpha 3 Subunit is a protein that in humans is encoded by the CHRNA3 gene. It is located on chromosome 15 and is part of the nicotinic acetylcholine receptors family.

Function

The protein encoded by the CHRNA3 gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). These receptors consist of a pentameric combination of different subunits (alpha, beta, gamma, and delta). The function of the alpha-3 subunit is to bind acetylcholine, a neurotransmitter that sends signals in the brain.

Clinical Significance

Variations in the CHRNA3 gene have been associated with an increased risk of nicotine dependence, lung cancer, and chronic obstructive pulmonary disease (COPD). Studies have shown that individuals with certain variations in the CHRNA3 gene are more likely to become dependent on nicotine, which can lead to serious health problems such as lung cancer and COPD.

Research

Research into the CHRNA3 gene and its associated proteins is ongoing. Understanding the role of this gene in nicotine dependence and lung diseases could lead to new treatments and prevention strategies.

See Also

• Nicotinic acetylcholine receptor
• Nicotine dependence
• Lung cancer
• Chronic obstructive pulmonary disease