CHRNB3
CHRNB3 is a gene that encodes the beta-3 subunit of the nicotinic acetylcholine receptor. This receptor is a type of ion channel that is activated by the neurotransmitter acetylcholine. The CHRNB3 gene is located on the short arm of chromosome 8 (8p11.21).
Function[edit | edit source]
The protein produced by the CHRNB3 gene is a component of the nicotinic acetylcholine receptor. This receptor is found in the neuronal synapse, where it plays a crucial role in transmitting signals between nerve cells. When acetylcholine binds to the receptor, it causes the channel to open, allowing ions to flow across the cell membrane. This ion flow generates an electrical signal that can be transmitted along the nerve cell.
Clinical significance[edit | edit source]
Mutations in the CHRNB3 gene have been associated with a variety of medical conditions. For example, some studies have suggested a link between variations in this gene and an increased risk of nicotine dependence, alcohol dependence, and obesity. However, more research is needed to confirm these findings and to understand the mechanisms involved.
See also[edit | edit source]
References[edit | edit source]
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