CHRNB4

CHRNB4 is a gene that encodes the beta-4 subunit of the neuronal nicotinic acetylcholine receptor. The neuronal nicotinic acetylcholine receptors are members of a superfamily of ion channels that mediate fast signal transmission at synapses.

Function

The CHRNB4 gene is part of a cluster of three nicotinic receptor genes on chromosome 15. This gene encodes the beta-4 subunit of the neuronal nicotinic acetylcholine receptor, which is a type of ligand-gated ion channel. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The receptor's ligand, acetylcholine, is released at the synapses in the peripheral and central nervous system and binds to these receptors. The binding causes the channel to open and allow ions to flow, creating an electrical signal.

Clinical significance

Mutations in the CHRNB4 gene have been associated with various health conditions. For example, some studies have suggested a link between variations in this gene and an increased risk of nicotine dependence, alcohol dependence, and certain types of lung cancer. However, more research is needed to confirm these findings and understand the mechanisms involved.

See also

• Nicotinic acetylcholine receptor
• Ion channel
• Neurotransmission