CMKLR1

CMKLR1 (Chemokine-like receptor 1) is a protein that in humans is encoded by the CMKLR1 gene. It is also known as ChemR23, DEZ, or ChemerinR. CMKLR1 is a member of the G protein-coupled receptor family, and it has been implicated in various biological processes, including inflammation, adipogenesis, and cardiovascular disease.

Function

CMKLR1 is a receptor for the chemoattractant protein Chemerin, and it mediates its effects through G protein-coupled signaling pathways. The activation of CMKLR1 by Chemerin can lead to intracellular calcium release and the activation of the phosphatidylinositol 3-kinase pathway.

In addition to its role in inflammation, CMKLR1 has been shown to play a role in the regulation of adipogenesis. It is expressed in adipose tissue, and its activation can promote the differentiation of pre-adipocytes into mature adipocytes.

Clinical significance

Alterations in the function or expression of CMKLR1 have been associated with various diseases. For example, increased expression of CMKLR1 has been observed in atherosclerotic plaques, suggesting a role in the development of cardiovascular disease. In addition, mutations in the CMKLR1 gene have been linked to obesity and metabolic syndrome.

See also

• G protein-coupled receptor
• Chemerin
• Adipogenesis
• Cardiovascular disease

External links

• CMKLR1 at the National Center for Biotechnology Information

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