CMTM3

CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) is a protein that in humans is encoded by the CMTM3 gene. It is a member of the chemokine-like factor (CKLF) gene superfamily, a novel gene family first identified in the human genome.

Function

CMTM3 is a small cytokine that is secreted and functions in immune response and cell signaling. It is involved in various cellular processes, including cell proliferation, cell migration, and apoptosis.

Clinical significance

Mutations in the CMTM3 gene have been associated with various diseases, including cancer, autoimmune diseases, and infectious diseases. In particular, it has been found to be downregulated in several types of cancer, suggesting that it may function as a tumor suppressor.

Structure

The CMTM3 protein is composed of 245 amino acids and has a molecular weight of approximately 27 kDa. It contains a MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain, which is involved in the regulation of membrane trafficking and membrane fusion.

Expression

CMTM3 is widely expressed in various tissues, including the heart, brain, lung, kidney, and testis. Its expression is regulated by various factors, including epigenetic modifications such as DNA methylation.

Research

Research on CMTM3 is ongoing, with studies focusing on its role in disease development and its potential as a therapeutic target.

See also

• Chemokine
• Cytokine
• Tumor suppressor