CNQX

CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is a competitive AMPA receptor antagonist and a non-competitive kainate receptor antagonist. It is commonly used in laboratory research to inhibit the action of the excitatory neurotransmitter glutamate.

Mechanism of Action

CNQX works by blocking the AMPA receptor, a type of ionotropic glutamate receptor. This prevents the excitatory neurotransmitter glutamate from binding to the receptor and activating it. CNQX also acts as a non-competitive antagonist at the kainate receptor, another type of ionotropic glutamate receptor.

Uses in Research

In laboratory research, CNQX is often used to inhibit the action of glutamate. This can be useful in studies of neuroscience and pharmacology, as it allows researchers to investigate the effects of reducing glutamate activity in the brain.

Side Effects

As with any drug, CNQX can have side effects. These can include neurotoxicity, which is damage to the nervous system caused by exposure to harmful substances.

See Also

• AMPA receptor
• Kainate receptor
• Glutamate
• Neurotoxicity

References

CNQX Resources
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