Calciphylaxis
Rare and serious disease characterized by calcification of blood vessels
| Calciphylaxis | |
|---|---|
| [[File:|250px|alt=|]] | |
| Synonyms | Calcific uremic arteriolopathy |
| Pronounce | N/A |
| Field | Nephrology, Dermatology |
| Symptoms | Painful skin ulcers, necrosis |
| Complications | Sepsis, organ failure |
| Onset | |
| Duration | |
| Types | N/A |
| Causes | Chronic kidney disease, hyperparathyroidism, diabetes mellitus |
| Risks | End-stage renal disease, obesity, female gender |
| Diagnosis | Skin biopsy, clinical evaluation |
| Differential diagnosis | Warfarin-induced skin necrosis, cholesterol embolism |
| Prevention | |
| Treatment | Sodium thiosulfate, wound care, pain management |
| Medication | |
| Prognosis | Poor |
| Frequency | Rare |
| Deaths | |
Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare and serious disease characterized by the calcification of small blood vessels within the dermis and subcutaneous tissue. This condition leads to the development of painful skin ulcers and can result in necrosis.
Symptoms[edit | edit source]
The primary symptoms of calciphylaxis include:
- Painful skin ulcers
- Areas of necrosis
- Erythema and induration around the affected areas
Complications[edit | edit source]
Calciphylaxis can lead to severe complications such as:
Causes[edit | edit source]
The exact cause of calciphylaxis is not fully understood, but it is commonly associated with:
Risk Factors[edit | edit source]
Several risk factors have been identified for calciphylaxis, including:
Diagnosis[edit | edit source]
Diagnosis of calciphylaxis is typically made through:
- Clinical evaluation
- Skin biopsy
Differential Diagnosis[edit | edit source]
Conditions that may present similarly and should be considered include:
Treatment[edit | edit source]
Treatment options for calciphylaxis focus on managing symptoms and may include:
Prognosis[edit | edit source]
The prognosis for calciphylaxis is generally poor, with a high risk of mortality due to complications such as sepsis and organ failure.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
