Calcium-binding protein 1
Calcium-binding protein 1 (CaBP1) is a protein that in humans is encoded by the CABP1 gene. It is a member of the calcium-binding protein family and plays a crucial role in the cellular physiology and homeostasis of calcium ions within the body.
Function[edit | edit source]
CaBP1 is a neuronal calcium sensor protein that is primarily expressed in the brain. It is involved in the regulation of intracellular calcium concentration, which is a critical factor in neuronal excitability, neurotransmitter release, gene expression, and cell survival.
Structure[edit | edit source]
CaBP1 is a small, soluble protein that contains four EF-hand calcium-binding motifs. These motifs allow the protein to bind to calcium ions and mediate the effects of changes in intracellular calcium concentration.
Clinical significance[edit | edit source]
Alterations in the expression or function of CaBP1 have been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Further research is needed to fully understand the role of CaBP1 in these conditions and to develop potential therapeutic strategies.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
