Candoxatril

Candoxatril is an orally active prodrug of candoxatrilat. It is a neprilysin inhibitor that is used in the field of pharmacology.

Etymology

The term "Candoxatril" is derived from the chemical name of the drug, which is a combination of the words "candoxatrilat" and "prodrug". The term "prodrug" is a pharmaceutical term that refers to a medication or compound that, after administration, is metabolized into a pharmacologically active drug.

Pharmacology

Candoxatril is a prodrug, which means it is an inactive drug that is metabolized in the body to produce an active drug, in this case, candoxatrilat. Candoxatrilat is a potent and selective inhibitor of neprilysin, an enzyme that degrades natriuretic peptides, bradykinin, and other vasoactive peptides. By inhibiting neprilysin, candoxatrilat increases the levels of these peptides, leading to increased vasodilation and natriuresis.

Clinical Use

Candoxatril has been studied for its potential use in the treatment of congestive heart failure and hypertension. However, its clinical use is limited due to its short half-life and the need for frequent dosing.

Related Terms

• Prodrug: An inactive drug that is metabolized in the body to produce an active drug.
• Neprilysin: An enzyme that degrades natriuretic peptides, bradykinin, and other vasoactive peptides.
• Natriuretic peptides: Peptides that promote natriuresis, the excretion of sodium in the urine.
• Vasodilation: The widening of blood vessels, which decreases blood pressure.
• Natriuresis: The excretion of sodium in the urine.

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