Canrenoic acid

Canrenoic acid
	; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;

A potassium-sparing diuretic drug

Canrenoic acid is a pharmaceutical drug that acts as a potassium-sparing diuretic. It is primarily used in the treatment of conditions such as congestive heart failure, hypertension, and edema.

Pharmacology[edit]

Canrenoic acid is a prodrug of canrenone, which is an active metabolite. It works by antagonizing the effects of aldosterone, a hormone that promotes the retention of sodium and water in the body. By inhibiting aldosterone, canrenoic acid helps to increase the excretion of sodium and water while retaining potassium, thus acting as a diuretic.

Mechanism of Action[edit]

Canrenoic acid binds to the mineralocorticoid receptor in the kidney, preventing aldosterone from exerting its effects. This leads to increased excretion of sodium and water, while potassium is retained, which is beneficial in conditions where potassium loss is a concern.

Clinical Uses[edit]

Canrenoic acid is used in the management of:

Congestive heart failure
Hypertension
Edema associated with liver cirrhosis or nephrotic syndrome

Side Effects[edit]

Common side effects of canrenoic acid include:

Hyperkalemia (elevated potassium levels)
Hyponatremia (low sodium levels)
Gastrointestinal disturbances

Contraindications[edit]

Canrenoic acid should not be used in patients with:

Related pages[edit]

Navigation-> Medicine - Wellness - Encyclopedia - Health topics - Diseases - Drugs - Gray's Anatomy - W8MD diet - Ketogenic diet - Recipes

Sponsored Health Resource

W8MD Weight Loss, Sleep & MedSpa

Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.

GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.

Book a W8MD appointment · View GLP-1 specials

Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Translate page: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian