From WikiMD's Wellness Encyclopedia


Centrophenoxine (IUPAC name: 2-[[dimethylamino)ethyl](4-chlorophenoxy)acetate), also known by its trade names Lucidril and Meclofenoxate, is a nootropic compound that is used to enhance memory and cognitive function. It is considered a cholinergic compound as it increases levels of acetylcholine in the brain, a neurotransmitter associated with memory and learning. Centrophenoxine is also used as a treatment for symptoms of senile dementia and Alzheimer's disease, although its effectiveness in these conditions is subject to ongoing research.

Mechanism of Action[edit | edit source]

Centrophenoxine works by increasing the synthesis and release of acetylcholine in the brain. It does this by acting as a choline donor, thereby enhancing the production of acetylcholine, a critical neurotransmitter for learning and memory processes. Additionally, centrophenoxine has been shown to have antioxidant properties, helping to reduce oxidative stress and remove lipofuscin, a type of waste product that accumulates in aging cells, including neurons.

Uses[edit | edit source]

The primary use of centrophenoxine is to improve cognitive function and memory. It is often used by individuals seeking to enhance their cognitive abilities, including students and older adults looking to maintain cognitive function. In the medical field, centrophenoxine has been explored as a treatment for cognitive decline associated with aging, such as in cases of senile dementia and Alzheimer's disease. However, more research is needed to fully understand its efficacy in these conditions.

Side Effects[edit | edit source]

While centrophenoxine is generally considered safe when used as directed, it can cause side effects in some individuals. Common side effects include nausea, dizziness, headaches, and gastrointestinal discomfort. It is important for users to start with a low dose to assess tolerance and avoid potential side effects.

Dosage[edit | edit source]

The recommended dosage of centrophenoxine varies depending on the intended use and the individual's health status. It is typically advised to start with a low dose, such as 250 mg twice a day, and adjust as needed based on tolerance and effectiveness. Consultation with a healthcare provider is recommended before starting centrophenoxine, especially for individuals with pre-existing health conditions or those taking other medications.

Research[edit | edit source]

Research on centrophenoxine has shown promising results in improving memory and cognitive function, particularly in older adults. Studies have also indicated its potential in reducing oxidative stress and clearing lipofuscin from neurons, suggesting a role in the prevention of age-related cognitive decline. However, more comprehensive clinical trials are needed to fully establish its benefits and safety profile.


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Contributors: Prab R. Tumpati, MD