Cerberus (protein)

Cerberus is a protein that in humans is encoded by the CER1 gene. It is named after the mythical creature Cerberus due to its role in acting as a gatekeeper in embryonic development.

Function

Cerberus is a secreted glycoprotein that plays a crucial role in embryogenesis and organogenesis. It functions as a growth factor antagonist, specifically inhibiting the activity of several members of the TGF-beta family. This includes BMP, Nodal, and Activin. By doing so, it helps regulate the formation and differentiation of various tissues and organs during embryonic development.

Clinical Significance

Mutations in the CER1 gene have been associated with several congenital disorders, including left-right asymmetry defects and congenital heart disease. Studies have also suggested a potential role for Cerberus in cancer progression, particularly in the context of tumor growth and metastasis.

Interactions

Cerberus has been shown to interact with other proteins, including Chordin, Follistatin, and Noggin, further modulating the activity of TGF-beta family members.

See Also

• TGF-beta
• BMP
• Nodal
• Activin
• Chordin
• Follistatin
• Noggin