Chlorodihydrocodide

A semi-synthetic opioid analgesic

Chlorodihydrocodide
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Chlorodihydrocodide is a semi-synthetic opioid derived from codeine. It is primarily used for its analgesic properties in the management of moderate to severe pain. As a member of the opioid class, it acts on the central nervous system to produce pain relief, sedation, and euphoria.

Chemical Structure

Structural formula of Chlorodihydrocodide

Chlorodihydrocodide is chemically related to morphine and codeine, sharing the core morphinan structure. The presence of a chlorine atom distinguishes it from other opioids, potentially affecting its pharmacokinetics and pharmacodynamics.

Pharmacology

Chlorodihydrocodide exerts its effects by binding to the mu-opioid receptors in the brain and spinal cord. This binding inhibits the transmission of pain signals and alters the perception of pain. The drug also affects the dopaminergic system, contributing to its potential for addiction.

Metabolism

The metabolism of chlorodihydrocodide occurs primarily in the liver, where it is converted into various metabolites. These metabolites are then excreted through the kidneys. The metabolic pathway involves cytochrome P450 enzymes, which are responsible for the biotransformation of many drugs.

Medical Uses

Chlorodihydrocodide is indicated for the relief of moderate to severe pain where alternative treatments are inadequate. It is often used in a clinical setting under strict medical supervision due to its potential for abuse and dependence.

Side Effects

Common side effects of chlorodihydrocodide include nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, hypotension, and allergic reactions.

Regulation

Due to its potential for abuse, chlorodihydrocodide is classified as a controlled substance in many countries. Its use is strictly regulated, and it is typically available only by prescription.

Related pages

• Opioid
• Codeine
• Morphine
• Analgesic
• Addiction