Chlorohydroxyphenylglycine

Chlorohydroxyphenylglycine (CHPG) is a chemical compound used in the field of pharmacology. It is a derivative of phenylglycine, a type of amino acid, and is characterized by the presence of a chlorine atom and a hydroxyl group on the phenyl ring.

Chemical Structure

The chemical structure of Chlorohydroxyphenylglycine consists of a phenylglycine core, which is a benzene ring attached to a glycine molecule. The benzene ring is substituted with a chlorine atom and a hydroxyl group, hence the name Chlorohydroxyphenylglycine.

Synthesis

The synthesis of Chlorohydroxyphenylglycine involves the reaction of phenylglycine with chlorine in the presence of a suitable catalyst. The hydroxyl group is then introduced through a subsequent reaction with water.

Pharmacological Use

In pharmacology, Chlorohydroxyphenylglycine is used as a ligand in the study of metabotropic glutamate receptors (mGluRs). It is particularly useful in the study of mGluR5, a subtype of metabotropic glutamate receptors.

Safety and Toxicity

As with any chemical compound, Chlorohydroxyphenylglycine should be handled with care. It may cause irritation to the skin and eyes, and may be harmful if swallowed or inhaled. Always use appropriate personal protective equipment when handling this compound.

See Also

• Phenylglycine
• Metabotropic glutamate receptor
• Pharmacology