Cicortonide

Cicortonide (also known as Alvesco and Ciclesonide) is a glucocorticoid used primarily in the treatment of asthma and allergic rhinitis. It is marketed under various brand names including Alvesco for asthma and Omnaris, Zetonna, and Alvesco for allergic rhinitis.

Pharmacology

Cicortonide is a prodrug which is activated in the lungs by esterases to form the active metabolite, desisobutyryl-ciclesonide (des-CIC). This active metabolite has a high glucocorticoid receptor binding affinity and a potent anti-inflammatory activity.

Medical uses

Cicortonide is used in the management of persistent asthma and allergic rhinitis. It is administered via inhalation for asthma and as a nasal spray for allergic rhinitis.

Side effects

Common side effects of cicortonide include headache, nasopharyngitis, sinusitis, pharyngolaryngeal pain, upper respiratory tract infection, and epistaxis.

History

Cicortonide was developed by AstraZeneca and was first approved by the FDA in 2006 for the treatment of asthma.

See also

• List of corticosteroids
• List of drugs: C

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