Clomiphene

Information about Clomiphene

Clomiphene is an oral agent used to treat infertility in women desiring pregnancy.

Liver safety of Clomiphene

Clomiphene has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury, which can be severe and even fatal.

Mechanism of action of Clomiphene

Clomiphene (kloe' mi feen) is an orally available, nonsteroidal antiestrogen that stimulates ovulation and is used largely as therapy of infertility in women. Clomiphene interacts with estrogen receptors in many tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina and cervix. The inhibition of estrogen effects by clomiphene leads to release of pituitary follicular stimulating hormone (FSH), which initiates growth and maturation of the ovarian follicle, follicular rupture and ovulation. In clinical trials, clomiphene resulted in pregnancies in approximately 30% of patients.

FDA approval information for Clomiphene

Clomiphene was approved for use in the United States in 1967, and current indications are for treatment of ovulatory dysfunction in women desiring pregnancy.

Dosage and administration for Clomiphene

Clomiphene is available in tablets of 50 mg generically and under the brand name Clomid. The recommended dose is 50 mg daily for 5 days.

Side effects of Clomiphene

Common side effects include headache, nausea, anorexia, diarrhea, rash and renal dysfunction. Uncommon, but potentially severe adverse events include hypersensitivity reactions, visual disturbance, abdominal pain, multiple pregnancies, and ovarian hyperstimulation syndrome.

Obstetrical and Gynecological Agents

• Emergency contraceptive agents
  • Levonorgestrel, Ulipristal

• Estrogens and Oral contraceptives

• • Selective estrogen receptor modulators
    • Bazedoxifene, Ospemifene, Raloxifene
  • Infertility agents

• Antiestrogens
  • Clomiphene, Letrozole, Tamoxifen

• Gonadotropins
  • Chorionic gonadotropin, Follicle stimulating hormone, Luteinizing hormone, Human gonadotropin releasing hormone

• Pregnancy termination agents
  • Mifepristone
• Progesterone and the Progestins

• Dailymed label info on Clomiphene
• FDA Clomiphene

Clomiphene Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski