Coefficient of inbreeding

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The coefficient of inbreeding (F) is a measure of the probability that two alleles at a given locus are identical by descent. It is a key concept in the field of population genetics and is used to quantify the level of inbreeding within a population. The coefficient of inbreeding is particularly important in the study of genetic diversity, conservation biology, and animal breeding.

Calculation

The coefficient of inbreeding is calculated using pedigree analysis. It is defined as the probability that an individual has two alleles at a locus that are identical by descent from a common ancestor. The formula for calculating the coefficient of inbreeding is:

F = Σ (1/2)^(n1+n2+1)

where:

• n1 is the number of generations from the common ancestor to one parent.
• n2 is the number of generations from the common ancestor to the other parent.

Implications

High levels of inbreeding can lead to inbreeding depression, which is the reduced biological fitness in a given population due to inbreeding. This can result in an increased prevalence of genetic disorders and a decrease in genetic variation. In contrast, low levels of inbreeding can help maintain genetic diversity and the overall health of a population.

Applications

The coefficient of inbreeding is used in various fields, including:

• Animal breeding: To manage breeding programs and avoid high levels of inbreeding.
• Conservation biology: To maintain genetic diversity in endangered species.
• Human genetics: To study the effects of inbreeding in human populations.

Related Concepts

• Inbreeding coefficient
• Genetic drift
• Heterozygosity
• Population bottleneck
• Founder effect

See Also

• Inbreeding
• Genetic diversity
• Pedigree chart
• Conservation genetics
• Population genetics