Conine

Conine is a chemical compound that is classified as an alkaloid. It is a toxic substance found in several plants, most notably in the hemlock plant, which is known for its historical use as a poison. Conine is a colorless, oily liquid with a strong, unpleasant odor.

Chemical Structure and Properties

Conine has the chemical formula C_8H_17N and is a member of the piperidine class of alkaloids. Its structure consists of a six-membered ring containing one nitrogen atom, making it a heterocyclic compound. The compound is optically active and exists in two enantiomeric forms.

Sources

The primary source of conine is the hemlock plant, specifically Conium maculatum. This plant is native to Europe and North Africa but has been introduced to other parts of the world, including North America. All parts of the hemlock plant contain conine, but the highest concentrations are found in the seeds and roots.

Toxicity

Conine is highly toxic to humans and animals. It acts as a neurotoxin by disrupting the function of the central nervous system. Symptoms of conine poisoning include muscle paralysis, respiratory failure, and, in severe cases, death. The lethal dose for humans is estimated to be around 100 mg.

Historical Significance

Conine is historically significant due to its association with the death of the ancient Greek philosopher Socrates. According to historical accounts, Socrates was sentenced to death by drinking a mixture containing hemlock, which led to his demise through conine poisoning.

Medical and Scientific Research

Despite its toxicity, conine has been the subject of scientific research due to its potential medicinal properties. Studies have explored its use in small, controlled doses for its analgesic and antispasmodic effects. However, its high toxicity limits its practical applications.

Related Pages

• Alkaloid
• Hemlock
• Neurotoxin
• Piperidine
• Socrates