Cutaneous small-vessel vasculitis

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Cutaneous small-vessel vasculitis
Cutaneous small-vessel vasculitis
Synonyms	Leukocytoclastic vasculitis, hypersensitivity vasculitis
Pronounce	N/A
Specialty	N/A
Symptoms	Purpura, Petechiae, Urticaria, Blisters, Ulcers
Complications	Kidney damage, Gastrointestinal bleeding, Peripheral neuropathy
Onset	Sudden
Duration	Variable
Types	N/A
Causes	Infection, Medication, Autoimmune disease
Risks	Age, Genetic predisposition, Environmental factors
Diagnosis	Skin biopsy, Blood tests
Differential diagnosis	Henoch-Schönlein purpura, Systemic vasculitis, Drug eruption
Prevention	N/A
Treatment	Corticosteroids, Immunosuppressants, Antihistamines
Medication	N/A
Prognosis	Generally good with treatment
Frequency	Common
Deaths	N/A

Cutaneous small-vessel vasculitis (CSVV), also known as hypersensitivity vasculitis, hypersensitivity angiitis, and leukocytoclastic vasculitis, is a condition that causes inflammation and damage to the small blood vessels in the skin. This can result in a variety of symptoms, including red or purple spots on the skin, itching, and in some cases, systemic symptoms such as fever and joint pain.

Causes

CSVV is often associated with reactions to medications, infections, or other diseases. It can also occur as a result of an autoimmune response, where the body's immune system mistakenly attacks its own tissues.

Symptoms

The most common symptom of CSVV is a rash, which typically appears as red or purple spots (petechiae) or larger patches (purpura) on the skin. The rash is often located on the lower legs, but can appear anywhere on the body. Other symptoms can include itching, burning, or pain at the site of the rash, and in some cases, systemic symptoms such as fever, fatigue, and joint pain.

Diagnosis

Diagnosis of CSVV is typically based on the appearance of the rash and a patient's medical history. In some cases, a skin biopsy may be performed to confirm the diagnosis.

Treatment

Treatment for CSVV is aimed at reducing inflammation and managing symptoms. This can include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, or other immunosuppressive medications. In some cases, treating the underlying cause of the vasculitis, such as discontinuing a medication or treating an infection, can also help to resolve the condition.

Gallery

• Micrograph of cutaneous small-vessel vasculitis
  Micrograph of cutaneous small-vessel vasculitis
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  Cutaneous small-vessel vasculitis
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  Leukocytoclastic vasculitis caused by reaction to minocycline
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  Cutaneous small-vessel vasculitis

See also

• Vasculitis
• Autoimmune disease
• Skin biopsy