Cyclopregnol

Cyclopregnol

Cyclopregnol is a synthetic, steroidal progestin that is related to progesterone. It was studied in the 1960s and 1970s but was never marketed.

Chemistry

Cyclopregnol, also known as 16α,17α-epoxypregn-4-en-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone and is a member of the 17α-hydroxyprogesterone group of progestins. Cyclopregnol is closely related to medroxyprogesterone acetate and megestrol acetate.

Pharmacology

As a progestogen, cyclopregnol has progestogenic effects similar to those of the natural hormone progesterone. It works by binding to and activating the progesterone receptor, a nuclear receptor that is expressed in many different tissues throughout the body.

History

Cyclopregnol was first synthesized in the 1960s and was studied in the 1960s and 1970s. However, it was never marketed for medical use. The reasons for this are not entirely clear, but may be related to its pharmacological properties or to commercial considerations.

See also

• List of progestogens
• List of steroidal progestogens

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