DHT

Dihydrotestosterone (DHT)

Dihydrotestosterone (DHT) is an androgen and sex steroid hormone. It is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5α-reductase.

Biological Function

DHT plays a crucial role in the development of male characteristics, including the growth of the prostate, seminal vesicles, and penis, as well as the development of secondary sexual characteristics such as facial hair, body hair, and deepening of the voice. It is also involved in the regulation of sebum production and the growth of hair follicles.

Synthesis

DHT is synthesized from testosterone by the enzyme 5α-reductase. This conversion occurs in various tissues, including the prostate gland, testes, hair follicles, and adrenal glands. The enzyme 5α-reductase exists in two isoforms, type 1 and type 2, both of which are involved in the conversion process.

Clinical Significance

DHT is implicated in several medical conditions. Elevated levels of DHT are associated with benign prostatic hyperplasia (BPH), androgenic alopecia (male pattern baldness), and acne. In contrast, deficiencies in DHT can lead to conditions such as 5-alpha-reductase deficiency, which can result in ambiguous genitalia and other developmental issues in males.

Inhibition

Inhibitors of 5α-reductase, such as finasteride and dutasteride, are commonly used to treat conditions like benign prostatic hyperplasia and androgenic alopecia. These medications work by reducing the conversion of testosterone to DHT, thereby lowering DHT levels in the body.

Related Pages

• Testosterone
• Androgen
• 5α-reductase
• Benign prostatic hyperplasia
• Androgenic alopecia
• Finasteride
• Dutasteride