DR6
DR6 (Death receptor 6) is a protein that in humans is encoded by the TNFRSF21 gene. It is a member of the tumor necrosis factor receptor superfamily (TNFRSF).
Function[edit | edit source]
DR6 is a cell surface receptor that is expressed in various tissues and can induce apoptosis and activate NF-κB. It has been shown to interact with TRADD proteins, and to activate NF-κB, MAPK8/JNK, and caspase pathways.
Interactions[edit | edit source]
DR6 has been shown to interact with:
Clinical significance[edit | edit source]
Alterations in the function of DR6 have been implicated in neurodegenerative diseases, including Alzheimer's disease.
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
