David M. Sabatini

WALS David M. Sabatini 3m04s (cropped)

== David M. Sabatini ==

David M. Sabatini is an American cell biologist and professor known for his research in the field of cell signaling and metabolism. He is particularly recognized for his discovery of the mTOR (mechanistic target of rapamycin) pathway, which plays a crucial role in regulating cell growth, proliferation, and survival.

Early Life and Education

David M. Sabatini was born in New York City. He completed his undergraduate studies at Brown University, where he earned a Bachelor of Science degree in Biochemistry. He then pursued his medical degree and Ph.D. at Johns Hopkins School of Medicine, where he conducted research under the mentorship of Solomon H. Snyder.

Research and Discoveries

Sabatini's most notable contribution to science is the discovery of the mTOR pathway. The mTOR pathway is a central regulator of cellular metabolism, growth, and proliferation. It integrates signals from nutrients, growth factors, and cellular energy status to control these processes. This pathway has significant implications for understanding diseases such as cancer, diabetes, and neurodegenerative disorders.

mTOR Pathway

The mTOR pathway consists of two distinct complexes: mTORC1 (mTOR Complex 1) and mTORC2 (mTOR Complex 2). mTORC1 is sensitive to the drug rapamycin and regulates protein synthesis, autophagy, and lipid metabolism. mTORC2, on the other hand, is involved in the regulation of the cytoskeleton and cell survival.

Academic Career

David M. Sabatini is a professor at the Massachusetts Institute of Technology (MIT) and a member of the Whitehead Institute for Biomedical Research. He has received numerous awards and honors for his contributions to science, including the Paul Marks Prize for Cancer Research and the Lurie Prize in Biomedical Sciences.

Controversies

In recent years, Sabatini has faced allegations of misconduct, which have led to investigations and significant media attention. These controversies have impacted his professional standing and affiliations with various institutions.

Personal Life

David M. Sabatini resides in Cambridge, Massachusetts. He is married and has children.

See Also

• Cell signaling
• Metabolism
• mTOR
• Cancer research
• Diabetes research
• Neurodegenerative disorders