Deoxymethoxetamine

Deoxymethoxetamine (DMXE) is a dissociative psychoactive drug that is structurally related to methoxetamine and dextromethorphan. It is a potent NMDA receptor antagonist and serotonin reuptake inhibitor, which means it can produce a range of psychedelic and dissociative effects when consumed.

Chemistry

Deoxymethoxetamine is a member of the arylcyclohexylamine class of dissociative anesthetics. Other members of this class include ketamine, phencyclidine (PCP), and methoxetamine (MXE). The chemical structure of DMXE consists of a phenyl ring bonded to a cyclohexane ring, with an amino group attached to the cyclohexane ring. The phenyl ring is substituted at R3 with a methoxy group.

Pharmacology

DMXE acts primarily as an NMDA receptor antagonist. This means it blocks the action of the neurotransmitter glutamate at the NMDA receptor, which is involved in learning, memory, and neuroplasticity. DMXE also acts as a serotonin reuptake inhibitor, which can increase the levels of serotonin in the brain and produce mood-enhancing effects.

Effects

The effects of DMXE can vary widely depending on the dose, the individual's physiology, and the context in which it is used. At lower doses, effects may include euphoria, altered perception, and increased sociability. At higher doses, DMXE can produce profound dissociation, hallucinations, and out-of-body experiences.

Risks and Safety

As with all psychoactive substances, there are risks associated with the use of DMXE. These can include psychological dependence, tolerance, and withdrawal symptoms with regular use. There is also the risk of overdose, which can result in severe respiratory depression, unconsciousness, and death.

Legal Status

The legal status of DMXE varies by country. In some countries, it is a controlled substance, while in others it is legal to possess and use.

See Also

• Dissociative
• Psychedelic drug
• NMDA receptor antagonist
• Serotonin reuptake inhibitor